CALS may refer to:
- Jo Cals (1914-1971), Dutch politician, Prime Minister of the Netherlands from 1965 until 1966.
- College of Agriculture and Life Sciences (disambiguation) - The name of a number of colleges at different universities
- The Christadelphian Auxiliary Lecturing Society - A group for providing Christadelphian speakers and lecturers Worldwide, particularly within the UK, and also for aiding preaching the truth of the Gospel as contained in the Bible in the UK and Worldwide.
- Client Access License - A Microsoft license technology
- CALS (DOD) (Continuous Acquisition and Life-cycle Support) - A United States Department of Defense initiative for electronically capturing military documentation and linking related information
- The CALS Table Model is a standard for representing tables in SGML/XML. Developed as part of the CALS DOD initiative
- The CALS Raster file format is a standard for the interchange of graphics data