Calcium Pump
There is a very large transmembrane electrochemical gradient of Ca2+ driving the entry of the ion into cells, yet it is very important for cells to maintain low concentrations of Ca2+ for proper cell signalling; thus it is necessary for the cell to employ ion pumps to remove the Ca2+.
The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations.
Read more about Calcium Pump: Why Cells Need Calcium Pumps, Muscle Cells Need Calcium Pumps, Understanding Calcium Pumps Through Crystallography, How The Calcium Pump Works
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—Ralph Waldo Emerson (1803–1882)