Calcineurin - Structure

Structure

Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes (PPP3R1, PPP3R2).

protein phosphatase 3, catalytic subunit, alpha isozyme
Identifiers
Symbol PPP3CA
Alt. symbols CALN, CALNA
Entrez 5530
HUGO 9314
OMIM 114105
RefSeq NM_000944
UniProt Q08209
Other data
EC number 3.1.3.16
Locus Chr. 4 q24
protein phosphatase 3, catalytic subunit, beta isozyme
Identifiers
Symbol PPP3CB
Alt. symbols CALNB
Entrez 5532
HUGO 9315
OMIM 114106
RefSeq NM_021132
UniProt P16298
Other data
EC number 3.1.3.16
Locus Chr. 10 q22.2
protein phosphatase 3, catalytic subunit, gamma isozyme
Identifiers
Symbol PPP3CC
Entrez 5533
HUGO 9316
OMIM 114107
RefSeq NM_005605
UniProt P48454
Other data
EC number 3.1.3.16
Locus Chr. 8 p21.3
protein phosphatase 3, regulatory subunit B, alpha
Identifiers
Symbol PPP3R1
Entrez 5534
HUGO 9317
OMIM 601302
RefSeq NM_000945
UniProt P63098
Other data
EC number 3.1.3.16
Locus Chr. 2 p14
protein phosphatase 3, regulatory subunit B, beta
Identifiers
Symbol PPP3R2
Entrez 5535
HUGO 9318
OMIM 613821
RefSeq NM_147180
UniProt Q96LZ3
Other data
EC number 3.1.3.16
Locus Chr. 9 q31

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