Prominent People Surnamed Cai
- Cai Cheng, a Chinese politician
- Cai Chusheng, an early Chinese film director
- Cai E, a Chinese revolutionary and warlord in early 20th century
- Cai Fu, a character in the Chinese literature classic the Water Margin
- Cai Gongshi, a Chinese emissary killed by Japanese soldiers during the Jinan Incident
- Cai Guo-Qiang, a Chinese contemporary artist and curator.
- Cai He, an officer in the Three Kingdoms period, brother of Cai Zhong and cousin of Cai Mao
- Cai Jing, a Song Dynasty official and a character in the Chinese literature classic the Water Margin
- Cai, Lady, the wife of Three Kingdoms period naval officer Huang Zu
- Cai Lun, the inventor of paper in the Han Dynasty
- Cai Mao, a naval officer in the Three Kingdoms period who served under Liu Biao, cousin of Cai He and Cai Zhong
- Cai Pei, a diplomat and politician in the Republic of China
- Cai Qian, a Chinese pirate in the Qing Dynasty
- Cai Qing, a character in the Chinese literature classic the Water Margin
- Cai Shangjun, a Chinese film director and screenwriter
- Cai Shu, a Chinese high jumper
- Cai Tingkai, a Chinese general during the Republican era
- Cai Wen, a Chinese academic
- Cai Wenji, a Han Dynasty poet and composer also known as Cai Yan, daughter of scholar Cai Yong
- Cai Xiang, a calligrapher, scholar, official and poet during the Song dynasty also known as Cai Zhonghui
- Cai Xitao, a Chinese botanist
- Cai Yong, a Han Dyansty scholar and father of Cai Wenji
- Cai Yuanpei, a chancellor of Peking University and first president of the Chinese Academy of Sciences (Academic Sinica)
- Cai Yun, a Chinese badminton player
- Cai Zhong, an officer in the Three Kingdoms period, brother of Cai He and cousin of Cai Mao
- Cai Zhuohua, a Chinese Christian preacher
- Chai Trong-rong or Trong Chai, a Taiwanese politician
- Choi, Ada, a Hong Kong actress
- Choi, Charlene, a Hong Kong singer, member of the Twins duo
- Choi Chi-sum, a Hong Kong evangelist
- Choi, Fátima, a Macanese government minister
- Choi, Sandra, an English creative director and designer for shoemaker Jimmy Choo Ltd
- Choi, Vin, a Hong Kong actor
- Choi York Yee, a Hong Kong footballer and sports commentator
- Choy, Anna, an Australian actress, TV presenter, and Australia Day Ambassador
- Choy, Elizabeth, a North Borneo-born Singaporean World War II heroine
- Choy González, Gonzalo, a Uruguayan footballer
- Choy So-yuk, a Hong Kong politician
- Choy Weng Yang, a Singaporean artist
- Choy, Wilbur Wong Yan, an American Methodist bishop
- Chua, Alfrancis, a Filipino basketball coach
- Chua, Amy, an American academic and author of Filipino Chinese descent
- Chua, Brent, a Filipino model
- Chua Ek Kay, a Singaporean artist
- Chua, Glen, a Canadian film director, actor, and writer
- Chua, Joi (Joi Tsai), a Singaporean singer
- Chua, Carlo Dino, a Filipino former vice mayor of Cavite
- Chua Jui Meng, a Malaysian health minister and prominent politician
- Chua Lam, a Singaporean-born Hong Kong columnist and movie producer
- Chua, Leon O., an American professor and inventor of Chua's circuit
- Chua Ling Fung, Simon, a bodybuilder from Singapore
- Chua, Mark, a Filipino murder victim
- Chua, Paige, a Singaporean model and actress
- Chua, Paul, a Singaporean bodybuilder
- Chua Phung Kim, a Singaporean weightlifter
- Chua Poi Suan, a Singaporean television actress
- Chua, Robert, a Singapore-born Asian television executive
- Chua Sock Koong, a Singaporean telecom executive
- Chua Soi Lek, a Malaysian health minister and prominent politician
- Chua Soon Bui, a Malaysian politician
- Chua, Tanya, a Singaporean singer
- Chua Tee Yong, a Malaysian politician
- Chua Tian Chang, or Tian Chua, a Malaysian politician
- Chuah, Tricia, a Malaysian squash player
- Sai On, a scholar-bureaucrat official of the Ryūkyū Kingdom
- Tjoa Ing Hwie or Tjoa Jien Hwie, the birth name of Surya Wonowidjojo, founder of Gudang Garam
- Tjoa, Marga, the real name of Indonesian writer Marga T
- Tjoa To Hing, the birth name of Indonesian businessman Rachman Halim
- Thái Phiên, a Vietnamese scholar and revolutionary
- Tsai, Angela, an American actress and television host
- Tsai Chia-Hsin, a Taiwanese badminton player
- Tsai Chih-chieh, a Taiwanese footballer (soccer player)
- Tsai Chih Chung, a Taiwanese cartoonist
- Tsai Chin, a Taiwanese popular music singer
- Tsai Horng Chung, a Chinese-Sarawakan painter
- Tsai Hsien-tang, a Taiwanese footballer
- Tsai Hui-kai, a Taiwanese footballer (soccer player)
- Tsai Ing-wen, a former Vice Premier of the Republic of China
- Tsai, Jeanne, an American academic
- Tsai, Jolin, a Taiwanese music singer
- Tsai, Kevin, a Taiwanese writer and television host
- Tsai Min-you, the real name of a Taiwanese singer Evan Yo
- Tsai, Ming, an American chef and host of television cooking shows
- Tsai Ming-Hung, a Taiwanese baseball player
- Tsai Ming-liang, a Taiwanese movie director
- Tsai Shengbai, a Chinese industrialist
- Tsai Wan-lin, a Taiwanese billionaire and founder of Cathay Life Insurance Company; brother of Tsai Wan-tsai and father of Tsai Hong-tu
- Tsai Yi-chen, a Taiwanese actress
- Tsoi, Herbert, former president of the Law Society of Hong Kong
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