A caboose is a manned railroad car at the end of a freight train in North America.
Caboose may also refer to:
- Caboose (ship's galley), a ship's kitchen above deck
- Caboose (Red vs. Blue), a character in the video series Red vs. Blue
- Caboose (film), a 1996 Canadian film directed by Richard Roy
- "Caboose", a song by Sugar Ray from Lemonade and Brownies