CA1 (gene)

Identifiers Symbols CA1; CA-I; CAB; Car1 External IDs OMIM: 114800 MGI: 88268 HomoloGene: 20414 ChEMBL: 261 GeneCards: CA1 Gene EC number 4.2.1.1

Gene Ontology
Molecular function	• carbonate dehydratase activity • zinc ion binding • metal ion binding
Cellular component	• cytoplasm • Golgi apparatus • cytosol
Biological process	• one-carbon metabolic process • bicarbonate transport • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 759 12346 Ensembl ENSG00000133742 ENSMUSG00000027556 UniProt P00915 P13634 RefSeq (mRNA) NM_001128829 NM_001083957 RefSeq (protein) NP_001122301 NP_001077426 Location (UCSC) Chr 8:
86.24 – 86.29 Mb Chr 3:
14.77 – 14.81 Mb PubMed search

Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including cellular respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.

They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.