C-Raf

C-Raf

Identifiers Symbols RAF1; CRAF; NS5; Raf-1; c-Raf External IDs OMIM: 164760 MGI: 97847 HomoloGene: 48145 ChEMBL: 1906 GeneCards: RAF1 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • Ras GTPase binding • mitogen-activated protein kinase kinase binding • identical protein binding • metal ion binding • protein heterodimerization activity
Cellular component	• nucleus • cytoplasm • mitochondrial outer membrane • cytosol • plasma membrane • pseudopodium
Biological process	• MAPK cascade • activation of MAPKK activity • response to hypoxia • protein phosphorylation • apoptotic process • cytoskeleton organization • signal transduction • epidermal growth factor receptor signaling pathway • activation of adenylate cyclase activity • small GTPase mediated signal transduction • Ras protein signal transduction • synaptic transmission • axon guidance • heart development • blood coagulation • cell proliferation • negative regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • platelet activation • negative regulation of protein complex assembly • positive regulation of peptidyl-serine phosphorylation • regulation of Rho protein signal transduction • wound healing • regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of cell differentiation • nerve growth factor receptor signaling pathway • regulation of cell motility
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5894 110157 Ensembl ENSG00000132155 ENSMUSG00000000441 UniProt P04049 Q99N57 RefSeq (mRNA) NM_002880.3 NM_029780.3 RefSeq (protein) NP_002871.1 NP_084056.1 Location (UCSC) Chr 3:
12.63 – 12.71 Mb Chr 6:
115.62 – 115.68 Mb PubMed search

RAF proto-oncogene serine/threonine-protein kinase also known as proto-oncogene c-RAF or simply c-Raf is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.