Burghley may refer to:
- William Cecil, 1st Baron Burghley (1520–1598), chief minister of queen Elizabeth I of England
- Burghley House, a sixteenth century country house in Cambridgeshire, built for the above
- Burghley Horse Trials, an annual three day event held there
- Burghley, an abandoned English village, believed to be under Burghley House
- David Cecil, 6th Marquess of Exeter, also known as David Burghley, British Conservative politician and 1928 Summer Olympics 400m hurdles champion