Buffon may refer to:
- Georges-Louis Leclerc, Comte de Buffon (1707–1788), French naturalist
- Gianluigi Buffon (born 1978), Italian football goalkeeper
- Lorenzo Buffon (born 1929), former Italian football goalkeeper, cousin of the grandfather of Gianluigi Buffon
- Buffon, Côte-d'Or, a town in the French département of Côte-d'Or
- Buffon (crater), a lunar crater
- Bufón, a Uruguayan rock band