BTB can refer to:
- Biblical Theology Bulletin
- Blood–testis barrier, an anatomical term
- Bovine Tuberculosis, a disease affecting, amongst others, cattle and badgers
- Branch target buffer, a computer science term
- Breakthrough bleeding of menstrual period
- The Brian Travis Band, a California folk rock band
- Bromothymol blue, a chemical indicator for weak acids and bases
- Bring To Boil, acronym used in the restaurant industry
- Belgian Treasury Bonds, a type of government bond
- Bus Tie Breaker, an aviation electronics term
- Bring That Booty, an acronym coined by Darryl Philbin from the American TV show The Office (U.S. TV Series)
- Beyond The Breakers, a method of fishing from a kayak outside of the ocean surf zone
- BTB School, an international school in Jakarta, Indonesia
- Bridge to Terabithia a 2007 film or book
- The IATA code of Bétou Airport, in the Republic of the Congo