Brisco may refer to:
- Brisco, Cumbria, a community in Cumbria, England
- Brisco, Indiana, an extinct town in Warren County, Indiana
- Biblical Research Institute Science Council (BRISCO), a Seventh-day Adventist group
- Brisco, lead character in The Adventures of Brisco County, Jr., a 1993 American TV show
- Brisco (rapper), real name British Alexander Mitchell
- The Brisco Brothers, a professional wrestling tag-team composed of brothers Jack Brisco and Gerald Brisco
- Robert Brisco, Canadian politician
- Brisco baronets