Brenner might refer to:
- Brenner Railway
- The Brenner Pass, one of the major passes through the Alps, linking Italy and Austria
- Brenner, a municipality in South Tyrol
- Brenner Base Tunnel railway tunnel through the base of the Brenner massif.
- Brenner (crater)
- Brenner tumour
- Givat Brenner and Brenner Regional Council, a kibbutz and a regional council in Israel.
- Crick, Brenner et al. experiment