Brendel may refer to:
- Alfred Brendel (b. 1931), pianist
- Brian Brendell (born 1986), Namibian footballer
- El Brendel (1890–1964), American entertainer
- Franz Brendel, 19th-century music critic and publisher
- Joachim Brendel (1921–1974), German Luftwaffe pilot
- Karl Brendel (1871–1925), German sculptor
- Otto Brendel (1901–1973), scholar of Etruscan art
- Sarah Brendel, German pop singer
- Wolfgang Brendel (born 1947), German opera singer