Bottomley is a surname, originating in West Yorkshire, and may refer to:
- Arthur Bottomley (1907 –1995), British Labour politician
- Brett Bottomley, an American Jazz Chapman Stickist
- Gordon Bottomley (1874 – 1948), English poet
- Henry Bottomley (born 1963), British statistician
- Horatio Bottomley, British fraudster
- Sir James Bottomley, KCMG, British diplomat
- Jim Bottomley, baseball player
- John Bottomley, a Canadian singer-songwriter
- Norman Bottomley, senior Royal Air Force commander
- Peter Bottomley, a British Conservative politician
- Virginia Bottomley (born 1948), British politician