Botha is a surname, especially common among Afrikaners in South Africa. People named Botha include:
- Andre Botha (disambiguation)
- Andries Botha, Khoikhoi leader in the 19th century Cape Colony
- John Philip "Bakkies" Botha (born 1979), rugby union player
- Francois Botha (born 1968), boxer and kickboxer
- Johan Botha (disambiguation)
- Leon Botha (1985–2011), artist and one of the world's oldest survivors of progeria
- Louis Botha (1862-1919), first Prime Minister of South Africa
- Luki Botha (born 1930), Formula One driver
- Hendrik Egnatius "Naas" Botha (born 1958), rugby union player
- Piet Botha (born 1955), rock musician, son of Pik Botha
- Pieter Willem Botha (1916-2006), also known as P.W., South African prime minister from 1978 to 1984 and state president from 1984 to 1989
- Roelof Frederik "Pik" Botha (born 1932), South African foreign minister in the later years of Apartheid
- Roelof Botha (born 1973), former chief financial officer of Paypal, grandson of Pik Botha
- Theo Botha (born 1960), shareholder activist
- Wendy Botha, South African surfer
The name could also refer to the World War 2 era Blackburn Botha aircraft.
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