Subcellular Localization
The subcellular localization of Bok protein is controversial. In proliferating cells, Bok is found in the nucleus. Upon induction of apoptosis, it was found to tightly associate with mitochondrial membranes. On the other hand, another group found Bok shuttling between the cytoplasm and the nucleus. In their experiments, increased nuclear (not mitochondrial) localization correlated with a stronger apoptotic activity.
Read more about this topic: BOK (gene)