Interactions
The binding of Bok to its interacting partners seems to be mediated by its BH3 domain. The splice variant Bok-S lacks this domain and is unable to form heterodimers with other proteins of the Bcl-2 family.
In yeast two-hybrid experiments, Bok was found to interact with the anti-apoptotic proteins Mcl-1, BHRF-1, and Bfl-1. However, interactions with other anti-apoptotic proteins such as Bcl-2, Bcl-xL, and Bcl-w were not detectable (1). Later studies aimed at confirming an interaction between Bok and pro-apoptotic Bak or Bax but were not successful.
Accordingly, coexpression of anti-apoptotic proteins such as Mcl-1 suppresses apoptosis induced by Bok overexpression. Consistent with the results mentioned above, coexpression of anti-apoptotic Bcl-2 does not prevent Bok-induced apoptosis.
Read more about this topic: BOK (gene)
Famous quotes containing the word interactions:
“Whereas children can learn from their interactions with their parents how to get along in one sort of social hierarchy—that of the family—it is from their interactions with peers that they can best learn how to survive among equals in a wide range of social situations.”
—Zick Rubin (20th century)
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)
“In child rearing it would unquestionably be easier if a child were to do something because we say so. The authoritarian method does expedite things, but it does not produce independent functioning. If a child has not mastered the underlying principles of human interactions and merely conforms out of coercion or conditioning, he has no tools to use, no resources to apply in the next situation that confronts him.”
—Elaine Heffner (20th century)