In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“And so I look on those sentiments which make the glory of the human being, love, humility, faith, as being also the intimacy of Divinity in the atoms; and, that, as soon as the man is right, assurances and previsions emanate from the interior of his body and his mind; as, when flowers reach their ripeness, incence exhales from them, and, as a beautiful atmosphere is generated from the planet by the averaged emanations from all its rocks and soils.”
—Ralph Waldo Emerson (1803–1882)
“We say justly that the weak person is flat, for, like all flat substances, he does not stand in the direction of his strength, that is, on his edge, but affords a convenient surface to put upon. He slides all the way through life.... But the brave man is a perfect sphere, which cannot fall on its flat side and is equally strong every way.”
—Henry David Thoreau (1817–1862)
“If you meet a sectary, or a hostile partisan, never recognize the dividing lines; but meet on what common ground remains,—if only that the sun shines, and the rain rains for both; the area will widen very fast, and ere you know it the boundary mountains, on which the eye had fastened, have melted into air.”
—Ralph Waldo Emerson (1803–1882)