Boco may refer to:
- Boco River, a river in Portugal
- Boco (Final Fantasy) or Boko, a fictional character in the video game series Final Fantasy
- BoCo (The Railway Series), a fictional diesel locomotive in The Railway Series books
- BoCo (Thomas and Friends), the corresponding character in the adapted TV series Thomas and Friends
- Romuald Boco, Beninese football player
- BoCo, a locomotive wheel arrangement description using the UIC classification system
- Boco, a small agricultural locality or Townland in the Quillota Province, Chile