- Reed Alexander, actor
- Jozy Altidore, soccer player
- Carling Bassett-Seguso with husband Robert Seguso, both tennis players
- Derek Bell, motor racing driver
- Marc Bell, entrepreneur
- Yuniesky Betancourt, baseball player
- Jeanne Bice, founder of Quaker Factory
- Ian Bishop, former English soccer player
- Ryland Blackinton, musician/guitarist for Cobra Starship
- Jon Bon Jovi, singer & musician
- Jason Bonham, rock and roll drummer & son of Led Zeppelin drummer John Bonham
- Ernest Borgnine, actor
- Don Brewer, drummer for Grand Funk Railroad
- Keith Byars, former football player
- Jennifer Capriati, tennis player
- Chris Carrabba, lead singer & guitarist of Dashboard Confessional
- Cris Carter, All-Pro football player
- Elena Dementieva, Russian tennis player
- Dion DiMucci, Rock & Roll Hall of Fame member
- Rashad Evans, former UFC Lightheavyweight Champion, current UFC fighter
- Chris Evert, tennis player
- Dr. Frank Field, TV personality, and NYC meteorologist for 5 decades
- Jeff Gordon, NASCAR racer
- Ariana Grande, actress, model and singer
- Taurean Green, basketball player
- John Grogan, author of Marley & Me
- Sébastien Grosjean, French tennis player
- Megan Hauserman, model & reality television actress
- John W. Henry, one of the owners of the Boston Red Sox
- Scott Hirsch, boxing manager & former e-mail spammer
- Lisa Hunt, author & artist
- Ryan Hunter-Reay, IndyCar Series driver
- Žydrūnas Ilgauskas, basketball player
- Khori Ivy, former football player
- Dennis Kozlowski, former CEO of Tyco International
- Bernhard Langer, golfer
- Jesse Levine, tennis player
- Scott Levine, computer criminal
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- Rush Limbaugh, Conservative radio talk show host
- Marilyn Manson, shock rocker
- Leonard Marshall, football player
- Tucker Max, writer
- Nicko McBrain, Iron Maiden drummer
- Vince McMahon, professional wrestler & promoter
- Scott Mersereau, professional football player for the New York Jets
- Andy Mill, Olympic ski racer and ex-husband of Chris Evert
- Corina Morariu, tennis player
- Jaclyn Nesheiwat, beauty queen, fashion model
- Paul Newman, entrepreneur
- Greg Norman, golfer
- Terrence Pegula, billionaire natural gas tycoon and owner of the Buffalo Sabres
- Sabby Piscitelli, football player for the Tampa Bay Buccaneers
- Maury Povich and wife, Connie Chung, tabloid and news media personalities
- Morgan Pressel, golfer
- Guillaume Raoux, tennis player
- Mark Richt, head football coach of the University of Georgia
- Andy Roddick, tennis player
- Pete Rose, baseball player
- Frank Rosenthal, ex-Las Vegas casino owner & handicapper
- Marion Ryan, 1950s British singer
- Sheryl Sandberg, COO of Facebook
- Stephanie Moulton Sarkis, psychotherapist and author
- Ryan Shore, contemporary film composer
- Vince Spadea, tennis player
- Scott Stapp, lead singer for the rock band Creed
- Howard Stelzer, avant-garde composer & founder of Intransitive Recordings
- Anna Tatishvili, tennis player
- Horia Tecău, tennis player
- Sahaj Ticotin, lead singer for the rock band Ra
- Donald Trump, billionaire real estate mogul, has a second residence in Boca Raton
- Danny Valencia, baseball player
- Brian Voss, bowler
- Ernie Wise, UK comedian & half of the double act Morecambe and Wise had a holiday home here, where he spent much of his time after Morecambe's death in 1984.
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