Blockbuster may refer to:
- Blockbuster (entertainment), any very successful movie, theatrical play, etc.
- Blockbusters (U.S. game show)
- Blockbusters (UK game show)
- Blockbuster (book), by Tom Shone
- Blockbuster LLC, a video and game rental chain
- Blockbuster bomb, a series of WWII-era air dropped bombs large enough to demolish a city block
- Blockbuster drug
- "Block Buster!", a song by The Sweet
- Blockbuster, a wrestling move also known as a flying neckbreaker
- "Operation Blockbuster", a military operation during World War II
- Comics
- Blockbuster (DC Comics), the name of four DC Comics characters
- Blockbuster (Man-Brute), a Marvel Comics character introduced in 1970
- Blockbuster (Marauder), a Marvel Comics character introduced in 1986