Blockade Effect

Some articles on blockade effect, effects, blockade:

Buprenorphine - Clinical Use - Blockade Effect and Opioid Withdrawal
... not only completely or nearly completely blocks or reverses opiate effects from other opioids, but also itself, causing full withdrawal symptoms ... Methadone also blocks the effects of other opioids at higher doses however, under ~40 mg, the block in effects is barely present ... commonly used methadone maintenance doses, the degree of blockade is similar to that produced by equivalent buprenorphine doses ...

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    Human knowledge and human power meet in one; for where the cause is not known the effect cannot be produced. Nature to be commanded must be obeyed; and that which in contemplation is as the cause is in operation as the rule.
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