Birrell is a surname. Notable people with the surname include:
- Adrian Birrell (born 1960), former South African first class cricketer and Irish cricket coach
- Alec Birrell (born 1885), Australian rules footballer
- Augustine Birrell (1850–1933), English politician, barrister, academic and author
- Billy Birrell (1897–1968), Scottish football player and manager
- Fred Birrell (1913–1985), Australian politician
- Gerry Birrell (1944–1973), Scottish racing driver
- James Birrell (born 1928), retired architect who worked in Queensland, Australia
- John Birrell (1815–1875), railway entrepreneur
- Mark Birrell (born 1958), solicitor, director and a former Cabinet Minister in Victoria, Australia
- Niki Birrell (born 1986), British Paralympic sailor
- Peter Birrell (born 1941), British musician in the band, Freddie and the Dreamers
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