Bioseparation of 1,3-propanediol - Process

Process

In nature, BioPDO is made from the fermentation of glycerol in yeast. However, DuPont has managed to engineer this glycerol functionality into a strain of Escherichia coli bacterium (hence referred to here as "E. coli"), thereby allowing industrial-scale fermentation of glycerol in a bioreactor. After the E. coli bacteria produce sufficient BioPDO product, a method to separate the BioPDO from the cellular broth that comes out of the bioreactor is needed. The separation scheme proposed by DuPont follows the following steps: microfiltration and ultrafiltration, ion exchange, flash evaporation, and distillation.

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