BLOC-1 or biogenesis of lysosome-related organelles complex 1 is a ubiquitously expressed multisubunit protein complex. BLOC-1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The complex was first described in 2004.
The identified protein subunits of BLOC-1 include:
- pallidin,
- muted (protein),
- dysbindin,
- cappuccino (protein)
- Snapin,
- BLOS1,
- BLOS2,
- BLOS3
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