Binding Immunoglobulin Protein

Binding Immunoglobulin Protein

Identifiers Symbols HSPA5; BIP; GRP78; MIF2 External IDs OMIM: 138120 MGI: 95835 HomoloGene: 3908 ChEMBL: 1781865 GeneCards: HSPA5 Gene

Gene Ontology
Molecular function calcium ion binding
protein binding
ATP binding
ATPase activity
protein domain specific binding
protein binding, bridging
ubiquitin protein ligase binding
ribosome binding
unfolded protein binding
chaperone binding
misfolded protein binding
Cellular component nucleus
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment
signalosome
cell surface
integral to endoplasmic reticulum membrane
midbody
endoplasmic reticulum chaperone complex
melanosome
Biological process platelet degranulation
ATP catabolic process
ER overload response
activation of signaling protein activity involved in unfolded protein response
blood coagulation
cerebellum structural organization
cerebellar Purkinje cell layer development
platelet activation
ER-associated protein catabolic process
negative regulation of transforming growth factor beta receptor signaling pathway
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
cellular response to glucose starvation
negative regulation of apoptotic process
regulation of protein folding in endoplasmic reticulum
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3309 14828 Ensembl ENSG00000044574 ENSMUSG00000026864 UniProt P11021 P20029 RefSeq (mRNA) NM_005347 NM_001163434 RefSeq (protein) NP_005338 NP_001156906 Location (UCSC) Chr 9:
128 – 128 Mb Chr 2:
34.77 – 34.78 Mb PubMed search

'Binding immunoglobulin protein' (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly-synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BiP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER. In humans, BiP is encoded by the HSPA5 gene.

Read more about Binding Immunoglobulin Protein:  Function, Mechanism, Interactions, Immunological Properties

Famous quotes containing the words binding and/or protein:

    Hate traps us by binding us too tightly to our adversary.
    Milan Kundera (b. 1929)

    Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.
    Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)