Big Sister may refer to:
- Big Sister (software), network monitoring software
- Big Sister (brothel), an online brothel in Prague
- "The Big Sister", an episode of Dexter's Laboratory
- "Big Sister," a song by Elvis Costello and the Attractions from Trust (Elvis Costello album)
- Big Sister's Island, one of the Sisters' Islands of Singapore
- Big Sisters part of the Big Brothers, Big Sisters program.
- Big Sister (radio) was a radio soap opera
- Big Sister, an enemy type in the game BioShock 2.
- Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
Famous quotes containing the words big and/or sister:
“... all big changes in human history have been arrived at slowly and through many compromises.”
—Eleanor Roosevelt (1884–1962)
“Evelyn Mulwray: She’s my daughter.
J.J. Gittes: I said I want the truth!
Evelyn Mulwray: She’s my sister. She’s my daughter. My sister, my daughter.
J.J. Gittes: I said I want the truth!
Evelyn Mulwray: She’s my sister and my daughter!”
—Robert Towne (b. 1936)