Betty Diamond - Principal Scientific Contributions

Principal Scientific Contributions

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells, and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease. She identified the first idiotype marker on anti-DNA antibodies in patients with lupus, and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of p atients with neuropsychiatric lupus. Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior. Diamond also studies the role that hormones may play in the development of lupus.

Read more about this topic:  Betty Diamond

Famous quotes containing the words principal and/or scientific:

    So in accepting the leading of the sentiments, it is not what we believe concerning the immortality of the soul, or the like, but the universal impulse to believe, that is the material circumstance, and is the principal fact in this history of the globe.
    Ralph Waldo Emerson (1803–1882)

    The scientific spirit is of more value than its products, and irrationally held truths may be more harmful than reasoned errors.
    Thomas Henry Huxley (1825–95)