Principal Scientific Contributions
Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells, and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease. She identified the first idiotype marker on anti-DNA antibodies in patients with lupus, and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of p atients with neuropsychiatric lupus. Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior. Diamond also studies the role that hormones may play in the development of lupus.
Read more about this topic: Betty Diamond
Famous quotes containing the words principal and/or scientific:
“The principal thing children are taught by hearing these lullabies is respect. They are taught to respect certain things in life and certain people. By giving respect, they hope to gain self-respect and through self-respect, they gain the respect of others. Self-respect is one of the qualities my people stress and try to nurture, and one of the controls an Indian has as he grows up. Once you lose your self-respect, you just go down.”
—Henry Old Coyote (20th century)
“Experimental work provides the strongest evidence for scientific realism. This is not because we test hypotheses about entities. It is because entities that in principle cannot be ‘observed’ are manipulated to produce a new phenomena
[sic] and to investigate other aspects of nature.”
—Ian Hacking (b. 1936)