Beta-ketoacyl-(acyl-carrier-protein) Synthase III
In enzymology, a β-ketoacyl- synthase III (EC 2.3.1.180) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + malonyl- acetoacetyl- + CoA + CO2
Thus, the two substrates of this enzyme are acetyl-CoA and malonyl-, whereas its 3 products are acetoacetyl-, CoA, and CO2. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.
This enzyme participates in fatty acid biosynthesis. β-ketoacyl-acyl-carrier-protein synthase III is involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The role of FabH in fatty acid synthesis has been described in Streptomyces glaucescens, Streptococcus pneumoniae, and Streptomyces coelicolor.
Read more about Beta-ketoacyl-(acyl-carrier-protein) Synthase III: Nomenclature, Role in Tuberculosis, Structure and Substrates, Inhibitors, Therapeutic Potential
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