Bernie may refer to:
- Bernie, Missouri, a US city
- Bernie (Doonesbury), a character in the comic strip
- Bernie, a Beanie Baby St. Bernard produced by Ty, Inc.
- Weekend at Bernie's, a 1989 comedy film
- Bernie (1996 film), a 1996 French film
- Bernie (2011 film), a film directed by Richard Linklater about convicted murderer Bernie Tiede
- Griffithsville, West Virginia, also called Bernie
- Bernard Sanders, the junior United States Senator from Vermont