List of Major Works of Art in The Basilica
- Early Christian mosaic cycle depicting Old Testament events, 5th century
- The Salus Populi Romani, a much venerated early icon of the Virgin and Child.
- Funerary monument of Clement IX (1671) by Carlo Rainaldi with the papal bust by Domenico Guidi.
- Temporary catafalque for Philip IV of Spain designed in 1665 by Rainaldi
- Funerary monument of Pope Nicholas IV, designed by Domenico Fontana in 1574.
- Bust of Costanzo Patrizi by Algardi.
- Sacristy frescoes by Passignano and Giuseppe Puglia,
- Saint Cajetan holding the Holy Child, by Bernini.
- High altar sculpture by Pietro Bracci, (c. 1750).
- Bust of Pius IX (1880) by Ignazio Jacometti.
- Pauline Chapel frescoes, by Guido Reni
- Frescoes for the monument of Clement VIII, Lanfranco
- Cesi Chapel tombs by Guglielmo della Porta
- Altar, confessio and Presepio (crib) sculptures by Arnolfo di Cambio, about 1290
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