Life Cycle
Infection occurs when a host ingests a cyst, which usually happens during the consumption of contaminated water or food. Once the cyst is ingested, it passes through the host’s digestive system. While the cyst receives some protection from degradation by the acidic environment of the stomach through the use of its outer wall, it is likely to be destroyed at a pH lower than 5, allowing it to survive easier in the stomachs of malnourished individuals who have less stomach acid. Once the cyst reaches the small intestine, trophozoites are produced. The trophozoites then colonize the large intestine, where they live in the lumen and feed on the intestinal flora. Some trophozoites invade the wall of the colon using proteolytic enzymes and multiply, and some of them return to the lumen. In the lumen trophozoites may disintegrate or undergo encystation. Encystation is triggered by dehydration of the intestinal contents and usually occurs in the distal large intestine, but may also occur outside of the host in feces. Now in its mature cyst form, cysts are released into the environment where they can go on to infect a new host.
Read more about this topic: Balantidium Coli
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