Spinal Fluid Driven Artificial Organ
Dr. Ommaya has two children who suffer from Type 1 diabetes. Motivated by his personal experience with the disease, Dr. Ommaya focused on the problem of transplantation of islet cells for the treatment of diabetes. A major challenge facing survival of islet cells is immune rejection. Dr. Ommaya thought that the CSF would provided an ideal setting for transplanted islets due to the immune protection provided by the blood brain barrier. He developed an artificial organ which would house transplanted islets, and the cells could be nourished by the CSF. Ayub, Illani Atwater, and colleagues identified that ventricular-peritoneal CSF shunts provided an immune protected site for the transplantation of mouse and rat islets in dogs and llamas.22, 30 Ayub and colleagues also identified that CSF glucose mirrors blood glucose. Islets cells were able to survive in this system and function in the llama model, but further work on the model is needed.1 Unfortunately Dr. Ommaya was not able to complete this research.
Read more about this topic: Ayub K. Ommaya
Famous quotes containing the words fluid, driven, artificial and/or organ:
“It is more than likely that the brain itself is, in origin and development, only a sort of great clot of genital fluid held in suspense or reserved.... This hypothesis ... would explain the enormous content of the brain as a maker or presenter of images.”
—Ezra Pound (1885–1972)
“Verily, the Indian has but a feeble hold on his bow now; but the curiosity of the white man is insatiable, and from the first he has been eager to witness this forest accomplishment. That elastic piece of wood with its feathered dart, so sure to be unstrung by contact with civilization, will serve for the type, the coat-of-arms of the savage. Alas for the Hunter Race! the white man has driven off their game, and substituted a cent in its place.”
—Henry David Thoreau (1817–1862)
“Kings are not born: they are made by artificial hallucination.”
—George Bernard Shaw (1856–1950)
“What we commonly call man, the eating, drinking, planting, counting man, does not, as we know him, represent himself, but misrepresents himself. Him we do not respect, but the soul, whose organ he is, would he let it appear through his action, would make our knees bend.”
—Ralph Waldo Emerson (1803–1882)