Spinal Fluid Driven Artificial Organ
Dr. Ommaya has two children who suffer from Type 1 diabetes. Motivated by his personal experience with the disease, Dr. Ommaya focused on the problem of transplantation of islet cells for the treatment of diabetes. A major challenge facing survival of islet cells is immune rejection. Dr. Ommaya thought that the CSF would provided an ideal setting for transplanted islets due to the immune protection provided by the blood brain barrier. He developed an artificial organ which would house transplanted islets, and the cells could be nourished by the CSF. Ayub, Illani Atwater, and colleagues identified that ventricular-peritoneal CSF shunts provided an immune protected site for the transplantation of mouse and rat islets in dogs and llamas.22, 30 Ayub and colleagues also identified that CSF glucose mirrors blood glucose. Islets cells were able to survive in this system and function in the llama model, but further work on the model is needed.1 Unfortunately Dr. Ommaya was not able to complete this research.
Read more about this topic: Ayub K. Ommaya
Famous quotes containing the words fluid, driven, artificial and/or organ:
“It is more than likely that the brain itself is, in origin and development, only a sort of great clot of genital fluid held in suspense or reserved.... This hypothesis ... would explain the enormous content of the brain as a maker or presenter of images.”
—Ezra Pound (1885–1972)
“Lawn as white as driven snow,
Cyprus black as e’er was crow,
Gloves as sweet as damask roses,
Masks for faces and for noses.”
—William Shakespeare (1564–1616)
“Europe has a set of primary interests, which to us have none, or a very remote relation. Hence she must be engaged in frequent controversies, the causes of which are essentially foreign to our concerns. Hence, therefore, it must be unwise in us to implicate ourselves, by artificial ties, in the ordinary vicissitudes of her politics or the ordinary combinations and collisions of her friendships or enmities.”
—George Washington (1732–1799)
“And this mighty master of the organ of language, who knew its every stop and pipe, who could awaken at will the thin silver tones of its slenderest reeds or the solemn cadence of its deepest thunder, who could make it sing like a flute or roar like a cataract, he was born into a country without literature.”
—Willa Cather (1873–1947)