Spinal Fluid Driven Artificial Organ
Dr. Ommaya has two children who suffer from Type 1 diabetes. Motivated by his personal experience with the disease, Dr. Ommaya focused on the problem of transplantation of islet cells for the treatment of diabetes. A major challenge facing survival of islet cells is immune rejection. Dr. Ommaya thought that the CSF would provided an ideal setting for transplanted islets due to the immune protection provided by the blood brain barrier. He developed an artificial organ which would house transplanted islets, and the cells could be nourished by the CSF. Ayub, Illani Atwater, and colleagues identified that ventricular-peritoneal CSF shunts provided an immune protected site for the transplantation of mouse and rat islets in dogs and llamas.22, 30 Ayub and colleagues also identified that CSF glucose mirrors blood glucose. Islets cells were able to survive in this system and function in the llama model, but further work on the model is needed.1 Unfortunately Dr. Ommaya was not able to complete this research.
Read more about this topic: Ayub K. Ommaya
Famous quotes containing the words fluid, driven, artificial and/or organ:
“On and on eternally
Shall your altered fluid run,
Bud and bloom and go to seed;
But your singing days are done;”
—Edna St. Vincent Millay (1892–1950)
“Lawn as white as driven snow,
Cyprus black as e’er was crow,
Gloves as sweet as damask roses,
Masks for faces and for noses.”
—William Shakespeare (1564–1616)
“A true politeness does not result from any hasty and artificial polishing, it is true, but grows naturally in characters of the right grain and quality, through a long fronting of men and events, and rubbing on good and bad fortune.”
—Henry David Thoreau (1817–1862)
“What we commonly call man, the eating, drinking, planting, counting man, does not, as we know him, represent himself, but misrepresents himself. Him we do not respect, but the soul, whose organ he is, would he let it appear through his action, would make our knees bend.”
—Ralph Waldo Emerson (1803–1882)