AXP may refer to:
- In Telecommunications (Associated to Cisco) The Cisco Application Extension Platform: Doing More with Less
- In computing, as an abbreviation associated with the DEC Alpha instruction set architecture
- In astronomy, as an abbreviation for Anomalous X-ray pulsar
- As NYSE AXP, the stock symbol for American Express
- As the National Rail code for Alexandra Parade railway station, United Kingdom
- As the Greek letters for the National Fraternity of Alpha Chi Rho (ΑΧΡ)
- Automotive X PRIZE