Autoimmune Hepatitis - Classification

Classification

Four subtypes are recognised, but the clinical utility of distinguishing subtypes is limited.

1. positive ANA and SMA, elevated immunoglobulin G (classic form, responds well to low dose steroids);
2. positive LKM-1 (typically female children and teenagers; disease can be severe), LKM-2 or LKM-3;
3. positive antibodies against soluble liver antigen (this group behaves like group 1) (anti-SLA, anti-LP)
4. no autoantibodies detected (~20%)