ATPase, Na+/K+ Transporting, Alpha 1
| Gene Ontology | |
|---|---|
| Molecular function | • 4-nitrophenylphosphatase activity • sodium:potassium-exchanging ATPase activity • protein binding • ATP binding • metal ion binding • chaperone binding |
| Cellular component | • endoplasmic reticulum • Golgi apparatus • plasma membrane • sodium:potassium-exchanging ATPase complex • membrane • integral to membrane • basolateral plasma membrane • sarcolemma • melanosome |
| Biological process | • regulation of the force of heart contraction • regulation of sodium ion transport • ATP biosynthetic process • regulation of blood pressure • negative regulation of glucocorticoid biosynthetic process • ion transmembrane transport • response to drug • negative regulation of heart contraction • positive regulation of heart contraction • positive regulation of striated muscle contraction • transmembrane transport |
| Sources: Amigo / QuickGO | |
116.92 – 116.95 Mb
101.58 – 101.6 Mb
| Gastric H+/K+-ATPase, N terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| tfe-induded structure of the n-terminal domain of pig gastric h/k-atpase | |||||||||
| Identifiers | |||||||||
| Symbol | H-K_ATPase_N | ||||||||
| Pfam | PF09040 | ||||||||
| InterPro | IPR015127 | ||||||||
Sodium/potassium-transporting ATPase subunit alpha-1 is an enzyme that in humans is encoded by the ATP1A1 gene. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. In melanocytic cells ATP1A1 gene expression may be regulated by MITF. Read more about ATPase, Na+/K+ Transporting, Alpha 1: Clinical Relevance Famous quotes containing the word alpha:“Imagination is a valuable asset in business and she has a sister, Understanding, who also serves. Together they make a splendid team and business problems dissolve and the impossible is accomplished by their ministrations.... Imagination concerning the world’s wants and the individual’s needs should be the Alpha and Omega of self-education.” | |||||||||