Supplement Use
Extracts of Astragalus membranaceus (syn. Astragalus propinquus) are marketed as life prolonging extracts in humans. A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, 'was associated with a significant age-reversal effect in the immune system, in that it led to declines in the percentage of senescent cytotoxic T cells and natural killer cells after six to twelve months of use.' In October 2010, Intertek/AAC Labs, an ISO 17025 internationally recognized lab, found the largest component of TA-65 to be Cycloastragenol. Telomerase activation was feared to pose an increased risk of cancer because telomere shortening is a mechanism that limits cell proliferation. However, short telomeres result in chromosome instability, hence there is also a potential mechanism for telomere lengthening to protect against cancer (as distinct from mutation-induced activation).
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