Aspera, a Latin adjective meaning rough, may refer to:
- ASPERA (band), a Norwegian Melodic Progressive Metal band
- Aspera European Astroparticle network, a physics organization
- Aspera (band), an American indie rock band
- Ulmus 'Aspera', a kind of elm tree
- (a)spera, a 2009 album by Mirah
- Per aspera ad astra, a Latin phrase
- Aspera, a digital data transfer company
- Aspera, a nomen superfluum for the Rubiaceae genus Galium
- Latin binomial abbreviations for species
- H. aspera (disambiguation)