Ascher is an alternative spelling of Asher and is the surname of:
- William Ascher, (born 1947), American professor of public policy
- Zika Ascher, (born 1910), Czech refugee textile designer and manufacturer in London and Paris
- Lida Ascher, (born 1913), Czech, born in Prague, textile designer and wife of Zika Ascher
- Sam Ascher. (born 1985), born in New York, grandson of Zika and Lida Ascher, director of Ascher Studio
- Joseph Ascher, Dutch composer and court pianist to Eugénie de Montijo
- Kate Ascher, an author and executive vice president of the New York City Economic Development Corporation
- Kenneth Lee Ascher (born 1944), American jazz pianist & composer
- Leo Ascher (1880-1942), Jewish composer
- Ludwig Ascher, also Louis Ascher (1865-1942), Polish Jewish social hygienist
- Mathias Ascher (pseudonym of Nathan Birnbaum), Austrian journalist and Jewish philosopher
- Saul Ascher (1767-1822), Jewish narrative writer and publicist
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