Design Challenges of Heart Valve Prostheses
- Thrombogenesis / haemocompatibility
- Mechanisms:
- Forward and backward flow shear
- Static leakage shear
- Presence of foreign material (i.e. intrinsic coagulation cascade)
- Cellular maceration
- Mechanisms:
- Valve-tissue interaction
- Wear
- Blockage
- Getting stuck
- Dynamic responsiveness
- Failure safety
- Valve orifice to anatomical orifice ratio
- Trans-valvular pressure gradient
- Minimal leakages
- Replaceable Models of Biological Valves
Read more about this topic: Artificial Heart Valve
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