The Restriction Point
In the early 1970s Pardee identified that the cell cycle has a point in the 'G1' Phase where the cell, as it were, 'commits' to moving to the 'S' Phase. Pardee published on this so-called 'Restriction Point', sometimes called the 'Pardee Point', in the Proceedings of the National Academy of Sciences in 1974 (A restriction point for control of normal animal cell proliferation, Proc Natl Acad Sci USA 1974; 71:1286-90).
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