Arthur Amos Noyes - Noyes–Whitney Equation

Noyes–Whitney Equation

Along with Willis Rodney Whitney, he formulated the Noyes–Whitney equation in 1897, which relates the rate of dissolution of solids to the properties of the solid and the dissolution medium. It is an important equation in pharmaceutical science. The relation is given by:

Where:

  • is the rate of dissolution.
  • A is the surface area of the solid.
  • C is the concentration of the solid in the bulk dissolution medium.
  • is the concentration of the solid in the diffusion layer surrounding the solid.
  • D is the diffusion coefficient.
  • L is the diffusion layer thickness.

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