Effect of Food and Interactions
Food enhances the absorption of both artemether and lumefantrine, and patients are advised to take the tablets with food as soon as a meal can be tolerated. Coartem has a potential to prolong the QT interval, so combinations with other drugs having that property can cause irregular heartbeat, potentially leading to lethal ventricular fibrillation. The combination with halofantrine, another antimalarial, can cause a life-threatening QT prolongation. Drugs and other substances influencing the activity of the liver enzyme CYP3A4, including grapefruit juice, can either increase or lower blood levels of artemether/lumefantrine, depending on the sort of substance. This can either lead to more severe side effects or to reduced efficiency.
Read more about this topic: Artemether/lumefantrine
Famous quotes containing the words effect of, effect, food and/or interactions:
“I guess what I’ve really discovered is the humanizing effect of children in my life—stretching me, humbling me. Maybe my thighs aren’t as thin as they used to be. Maybe my getaways aren’t as glamorous. Still I like the woman that motherhood has helped me to become.”
—Susan Lapinski (20th century)
“To get time for civic work, for exercise, for neighborhood projects, reading or meditation, or just plain time to themselves, mothers need to hold out against the fairly recent but surprisingly entrenched myth that “good mothers” are constantly with their children. They will have to speak out at last about the demoralizing effect of spending day after day with small children, no matter how much they love them.”
—Wendy Coppedge Sanford. Ourselves and Our Children, by Boston Women’s Health Book Collective, introduction (1978)
“One farmer says to me, “You cannot live on vegetable food solely, for it furnishes nothing to make bones with;” and so he religiously devotes a part of his day to supplying his system with the raw material of bones; walking all the while he talks behind his oxen, which, with vegetable-made bones, jerk him and his lumbering plow along in spite of every obstacle.”
—Henry David Thoreau (1817–1862)
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)