Effect of Food and Interactions
Food enhances the absorption of both artemether and lumefantrine, and patients are advised to take the tablets with food as soon as a meal can be tolerated. Coartem has a potential to prolong the QT interval, so combinations with other drugs having that property can cause irregular heartbeat, potentially leading to lethal ventricular fibrillation. The combination with halofantrine, another antimalarial, can cause a life-threatening QT prolongation. Drugs and other substances influencing the activity of the liver enzyme CYP3A4, including grapefruit juice, can either increase or lower blood levels of artemether/lumefantrine, depending on the sort of substance. This can either lead to more severe side effects or to reduced efficiency.
Read more about this topic: Artemether/lumefantrine
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“Considered physiologically, everything ugly weakens and saddens man. It reminds him of decay, danger, impotence; it actually reduces his strength. The effect of ugliness can be measured with a dynamometer. Whenever anyone feels depressed, he senses the proximity of something “ugly.” His feeling of power, his will to power, his courage, his pride—they decline with ugliness, they rise with beauty.”
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