Effect of Food and Interactions
Food enhances the absorption of both artemether and lumefantrine, and patients are advised to take the tablets with food as soon as a meal can be tolerated. Coartem has a potential to prolong the QT interval, so combinations with other drugs having that property can cause irregular heartbeat, potentially leading to lethal ventricular fibrillation. The combination with halofantrine, another antimalarial, can cause a life-threatening QT prolongation. Drugs and other substances influencing the activity of the liver enzyme CYP3A4, including grapefruit juice, can either increase or lower blood levels of artemether/lumefantrine, depending on the sort of substance. This can either lead to more severe side effects or to reduced efficiency.
Read more about this topic: Artemether/lumefantrine
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“I guess what I’ve really discovered is the humanizing effect of children in my life—stretching me, humbling me. Maybe my thighs aren’t as thin as they used to be. Maybe my getaways aren’t as glamorous. Still I like the woman that motherhood has helped me to become.”
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“The second [of Zeno’s arguments about motion] is the one called “Achilles.” This is to the effect that the slowest as it runs will never be caught by the quickest. For the pursuer must first reach the point from which the pursued departed, so that the slower must always be some distance in front.”
—Zeno Of Elea (c. 490–430 B.C.)
“This is the only “wet” community in a wide area, and is the rendezvous of cow hands seeking to break the monotony of chuck wagon food and range life. Friday night is the “big time” for local cowboys, and consequently the calaboose is called the “Friday night jail.””
—Administration in the State of Texa, U.S. public relief program (1935-1943)
“In child rearing it would unquestionably be easier if a child were to do something because we say so. The authoritarian method does expedite things, but it does not produce independent functioning. If a child has not mastered the underlying principles of human interactions and merely conforms out of coercion or conditioning, he has no tools to use, no resources to apply in the next situation that confronts him.”
—Elaine Heffner (20th century)