ARHGEF7

ARHGEF7

Identifiers Symbols ARHGEF7; BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB External IDs OMIM: 605477 MGI: 1860493 HomoloGene: 2895 GeneCards: ARHGEF7 Gene

Gene Ontology
Molecular function	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding • phospholipid binding • protein kinase binding
Cellular component	• ruffle • cytosol • focal adhesion • cell cortex • lamellipodium • neuron projection • neuronal cell body • protein complex
Biological process	• apoptotic process • signal transduction • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • nervous system development • lamellipodium assembly • regulation of Rho protein signal transduction • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of apoptotic process • positive regulation of GTPase activity • nerve growth factor receptor signaling pathway • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8874 54126 Ensembl ENSG00000102606 ENSMUSG00000031511 UniProt Q14155 Q9ES28 RefSeq (mRNA) NM_001113511 NM_001113517 RefSeq (protein) NP_001106983 NP_001106989 Location (UCSC) Chr 13:
111.77 – 111.96 Mb Chr 8:
11.73 – 11.84 Mb PubMed search

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.