ARHGEF4

ARHGEF4

Identifiers Symbols ARHGEF4; ASEF; ASEF1; GEF4; STM6 External IDs OMIM: 605216 MGI: 2442507 HomoloGene: 49414 GeneCards: ARHGEF4 Gene

Gene Ontology
Molecular function	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding • phospholipid binding • protein domain specific binding • Rac guanyl-nucleotide exchange factor activity
Cellular component	• cytosol • ruffle membrane
Biological process	• apoptotic process • small GTPase mediated signal transduction • lamellipodium assembly • regulation of Rho protein signal transduction • intracellular signal transduction • filopodium assembly • nerve growth factor receptor signaling pathway • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 50649 226970 Ensembl ENSG00000136002 ENSMUSG00000037509 UniProt Q9NR80 Q7TNR9 RefSeq (mRNA) NM_015320 NM_183019 RefSeq (protein) NP_056135 NP_898840 Location (UCSC) Chr 2:
131.59 – 131.8 Mb Chr 1:
34.68 – 34.81 Mb PubMed search

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.