Excretion
Excretion is primarily hepatic and biliary with almost no elimination via the renal route and it is not dialyzable . Elimination half-life average of 58 days (ranging from 25–100 days ) for amiodarone and 36 days for the active metabolite, desethylamiodarone (DEA) . There is 10-50% transfer of amiodarone and DEA in the placenta as well as presence in breast milk . Accumulation of amiodarone and DEA occurs in adipose tissue and highly perfused organs (i.e. liver, lungs), therefore, if an individual was taking amiodarone on a chronic basis, if it is stopped it will remain in the system for weeks to months.
Read more about this topic: Aratac, Metabolism