Appomattox may refer to:
- Appomattox, Virginia, a town
- Appomattox County, Virginia
- Appomattox Basin, a name for the Tri-Cities, Virginia region
- Appomattox Court House, a court house in Virginia
- Appomattox Court House National Historical Park, a National Historical Park in Virginia
- Appomattox Manor, a manor in City Point, Virginia
- Appomattox River, a river in Virginia
- Battle of Appomattox Court House, a battle of the American Civil War
- Battle of Appomattox Station, a battle of the American Civil War
- Appomattox Campaign, a campaign of American Civil War
- Appomattox (ship), a large wooden steamship
- Appomattox (banana boat), a British steamship of the early 20th century
- Appomattox (opera), a new opera by Philip Glass