APK may refer to:
- APK (file format), as in "filename.apk", Android Package, a packaging file format for the Android operating system
- Afrikaanse Protestantse Kerk, the whites-only Calvinist church in South Africa
- Algemene Periodieke Keuring, the vehicle inspection in The Netherlands
- Amplitude shift keying, see Amplitude and phase-shift keying
- Apopka High School, see Apopka High School
- Arbetarpartiet Kommunisterna, see Communist Party of Sweden (1995)
- Arbejderpartiet Kommunisterne, see Workers' Communist Party (Denmark)