Apical Ectodermal Ridge
Apical Ectodermal Ridge (AER)
The apical ectodermal ridge (AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ensure proper development of a limb. After the limb bud induces AER formation, the AER and limb mesenchyme – including the zone of polarizing activity (ZPA) - continue to communicate with each other to direct further limb development.
Read more about Apical Ectodermal Ridge: Formation, Roles, Relationship Between Hox Gene Expression and Limb Patterning, Relevant Experiments, Relevant Molecules
Famous quotes containing the word ridge:
“All sound heard at the greatest possible distance produces one and the same effect, a vibration of the universal lyre, just as the intervening atmosphere makes a distant ridge of earth interesting to our eyes by the azure tint it imparts to it.”
—Henry David Thoreau (1817–1862)