Apical Ectodermal Ridge
The apical ectodermal ridge (AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ensure proper development of a limb. After the limb bud induces AER formation, the AER and limb mesenchyme – including the zone of polarizing activity (ZPA) - continue to communicate with each other to direct further limb development.
Other articles related to "apical ectodermal ridge":
... activates secretion of WNT3A, which acts upon the apical ectodermal ridge (AER) and induces FGF8 expression ... FGF8 = Secreted by the apical ectodermal ridge cells ...
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