Apamin - Toxicity

Toxicity

Symptoms following bee sting or apamin poisoning may include:

  • local effects: burning or stinging pain, swelling, redness.
  • severe systemic reactions: swelling of the tongue and throat, difficulty breathing, and shock.
  • development of optic neuritis and atrophy.
  • atrial fibrillation, cerebral infarction, acute myocardial infarction, Fisher's syndrome, acute inflammatory polyradiculopathy (Guillain-Barre syndrome), claw hand (through a central action of apamin on the spinal cord and a peripheral action in the form of median and ulnar neuritis, causing spasms of the long flexors in the forearm).
  • dramatic haemorrhagic effect in the lungs.

Patients poisoned with bee venom can be treated with anti-inflammatory medication, antihistamines and oral prednisolone.

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